Grace Andrews and Jim Halsey are a collegiate couple who are tormented by the mysterious hitchhiker John Ryder, a.k.a. The Hitcher. The young couple hit the road in a 1970 Oldsmobile 442, en route to spring break. But their pleasure trip soon turns into a waking nightmare. The initial encounters with Ryder are increasingly off-putting for Grace and Jim, and they bravely fight back when he ambushes them. But they are truly blindsided when he implicates them in a horrific slaying and continues to shadow them. The open road becomes a suspenseful, action-packed battleground of blood and metal as, in trying to elude not only Ryder but also New Mexico State Police Lieutenant Esteridge's officers, Grace and Jim must fight for their lives and face their fears head-on.